This is the lab page of David T Blake, PhD. The lab investigates questions concerning brain electrophysiology and behavior. The most recent focus has been on basal forebrain deep brain stimulation, its physiological and behavioral effects, and the potential to use such deep brain stimulation to treat neurological disorders. In multiple studies in Rhesus monkeys, aged Rhesus monkeys, mice, and humans we routinely measure cognitive changes from deep brain stimulation equivalent to reversing the age related declines in cognition over the last third of the lifespan. Honestly, I think it is going to cure Alzheimer's, and by that I mean its application in patients will prevent cognitive decline from altering their activities of daily living. Human trials of our methods are ongoing in some centers. If you would like to apply our methods to your human trials, contact me.

Main questions for the lab

Weeks of application of deep brain stimulation can dramatically improve executive function even in fully functioning young adults. Can it do the same in Alzheimer's patients?
What are the cell biological pathways involved in instantiating those learning rules?
The release of acetylcholine and noradrenaline by deep brain stimulation of the basal forebrain or locus coeruleus cause alter neurotrophic tone, neural tone, and blood vessel diameter. What are the causal and dependent relationships between local neural activity, blood vessel tone, and neuromodulation?

Scholars interested in pursuing any of these ongoing directions should get in touch.

To find a list of papers, try Pubmed or Google scholar.
I have a webpage at MCG/AU also, but I urge people to consider this web site as more likely up to date.

Graduate school in touch

I did my PhD at Johns Hopkins in Biomedical Engineering. The lab was Kenneth Johnson's, and Steve Hsiao was an Assistant Professor in the same lab. We began work on the 10th floor of PCTB, and moved the lab around 1993 to the Krieger Mind/Brain Institute. My work was on the neural basis of tactile roughness perception and resulted in several manuscripts with Ken and Steve. Touch has been a mainstay of my research since then, although the questions have revolved around neuroplasticity. Ken and Steve both passed away from cancer far too young, and I miss them and their unique approaches to neuroscience.

Neuroplasticity work

In 1996, I went to the lab of Michael Merzenich. There, with R. Christopher deCharms, we succeeded in developing one of the earliest high yield sensory cortex implants. The following experiments, done also with fabrizio strata, Anne Churchland, and Richard Kempter, were among the first to resample, with high spatial resolution, the same cortical locations throughout a period of learning. The discoveries that followed were unexpected. A robust nonselective response enhancement occurred within 24 hours of the time that an animal learned to associate a new sensory stimulus with reward. Over longer periods of time, the representations of stimuli associated with omission of reward, or task distractors, became selectively suppressed. Surprisingly, any tendency for the representations of targets to be enhanced, relative to the representations of control stimuli, were weak or absent. The following figure, taken from Blake et al 2002, shows the rapidity and strength of the nonselective response enhancement. Cortical responses double in 24 hours after learning.



In 2006, I moved to Augusta University. Following work in the lab demonstrated that the neuroplasticity required a cognitive association between the sensory stimuli and reward and not simple stimulus-reward pairing. Work led by Elsie Spingath with Fred Kang found that the nonselective response enhancement was specific to forming the association between the target and the reward, while the responses to the task distractor became selectively suppressed. The neuroplasticity phenomena were observed in macaque somatosensory cortex, to be added to owl monkey somatosensory and auditory cortex, and rodent auditory cortex (by Zeke Carpenter-Hyland). The same mechanisms are at work in each system, and to our ability to sample responses, the plasticity effects are identical.

Executive function and learning in prefrontal cortex

Christos Constantinidis (Wake Forest) and I began collaborating in 2008 on studies investigating learning and pharmacology using cortical implants in dorsolateral prefrontal cortex. These studies are ongoing, and are assessing the potential for deep brain stimulation to positively impact executive function, and the neuropharmacological profile of those effects. A few papers are now published from this collaboration. Based on our observations that a few months of deep brain stimulation can enormously improve executive function, we are re-directing our studies to study cognition in aging and Alzheimer's Disease.

Studies with Jonathan Crawford and Ruifeng Liu demonstrated that deep brain stimulation led to improvements in working memory that translated to a 30-45% rank percentile increase. See some citations here.

Studies with Jacob Kumro demonstrated that the likely mediator of these effects are the activation of the neurotrophins BDNF and NGF by stimulation. See the preprint.

Our overarching hypothesis is that basal forebrain activation triggers a neurotrophic response that modulates forebrain aging. Repetitive activation reduces key indicators of forebrain aging, such as working memory, glucose utilization, and neurotrophic receptor density, and we further hypothesize this specific couping, between cholinergic release in cortex and a neurotrophic response, is antagonized in Alzheimer's dementia.


Current work occurs in the mouse lab, led by Khadijah Shanazz, PhD. She uses the GACh3.0 sensor in cerebral cortex, and also places a stimulating electrodes in the basal forebrain. She can stimulate and image the cholinergic response to stimulation each 0.6 seconds. One paper is on BioRXiV, and she has recently added two things to her studies. She measures the vascular response to stimulation at the same time as the cholinergic response, and she transitioned to working with awake mice. We've received a lot of help from the labs of Sergei Kirov and Phil O'Herron in getting things working, and they are supportive co-authors.
Dr. Shanazz can be emailed as kshanazz AT augusta


The work in the monkey lab is led by graduate student Kendyl Pennington. She has a paper on BioRXiV also, and hers details the changes in senescent macaques after deep brain stimulation of the nucleus basalis of Meynert is applied. Her upcoming project samples cerebrospinal fluid before, during, and after deep brain stimulation. She is looking at changes in the proteome of the fluid as indications of processes occuring in the chemical communication between neurons and other cells in the neuropil. We are particularly interested if there are clues to the causes of Alzheimer's dementia that are reflected by the proteome of the CSF fluid. Stay tuned for answers!
Kendyl can be emailed as kpennington AT augusta

Contact info


Contact me at dblake.mcg AT gmail DOT com, or call the office 706-721-9399. Email is preferred, and if you want a phone call, please email to set one up.